UPDATE: PHARMA SCAM = PILLARS BUILT INTO US DRUG POLICY
1. “Most new drugs are ‘life-saving’ and must be rushed to patients who need them.” = LIE
a. Most new drugs not for life-threatening conditions. Perhaps 10 percent.
b. Independent reviewers judge about 90% new drug products as little or no better against clinical measures of improvement or less harm. Consistent pattern for 40 yrs
c. Therefore about 1% new drugs would be “life-saving.” (10% x 10% = 1%)
d. Most R&D spent on developing minor variations. Most marketing spent on them.
e. Inverse Benefit Law of widespread marketing that dilutes benefits and proliferates risks of harms.
2. “The FDA screens out unsafe and ineffective drugs. Approved drugs are safe and effective.” = LIE
a. Better than placebo means new drugs may be less effective than existing ones. No useful evidence for prescribing or how new drug compares to others.
b. Non-inferior means new drugs are no worse than -20% the comparator drug. No useful evidence on how superior new drugs are, if they are.
c. Evidence on risks of harms in minimal. From company trials designed to minimize evidence of harms.
d. All evidence on a carefully chosen, ideal population most likely to benefit and not have adverse reactions. Real patients and real patterns of use usually less beneficial and more harmful.
e. Since 90% of new drug products are little or no better, they cannot be safe.
f. Aside from in-class choice, are the FDA and EMA flooding the market with ineffective, unsafe drugs?
3. An epidemic of harmful side effects (with few offsetting benefits).
a. the 4th leading cause of death. About 113,000 deaths just in hospitalized patients.
b. About 2.5 million serious reactions and 1.7 million hospitalizations.
c. About 50 million adverse reactions, mostly mild but impair performance & judgment
d. A major cause of falls, accidents, anti-social behaviors.
e. Risks of harm increase through cascade effect and take multiple drugs.
f. Harmful side effects generate more sales.
4. Market is flooded with new drug products of little or no advantage that consume 80% of increased pharmaceutical costs. Harmful side effects generate more sales.
a. A self-reinforcing syndrome: high prices, protected by government from free market competition, fund the development of these drugs and their costly marketing, which generate more revenues to develop more of these drugs.
5. “US prices have to be high to recover $1.7 billion in R&D costs per new drug and recover what lower prices abroad do not recover.”
a. The $1.7 billion figure is inflated from unverifiable R&D costs which companies have strong incentives to inflate from the start. Half the “costs” are estimated profits that companies would have made if they had not invested in R&D for new products vital for their survival. Another half are costs subsidized by taxpayers. Then the $1.7 billion estimate is based on the most costly 20 percent of new drugs but attributed to all drugs – a three-fold distortion. Just these three factors mean you divide by 12 to get $0.14 billion. Another third of the total comes from backing in a high amount for the unknown cost of discovery. And there’s more… See “Demythologizing the high costs…”
b. The BMJ article “Foreign free riders…” drew on data from the National Science Foundation, companies and government to conclude that companies earn back all expenses and make a profit at Canadian and European prices. US high prices simply make extra profits from government protections from free-market competition.
c. The USA is the primary market where drug companies raise prices each year on last year’s models because they are protected from free-market competition.
d. Pharmaceutical companies will make solid profits under bundled payments that rein in high prices.
e. Cancer drugs should be relatively cheap. First, most R&D is paid for by others, not companies. Second, trials are smaller and shorter than for other drugs. Third, in most cases we have no verifiable evidence that manufacturing costs are higher. Why, then, are cancer drugs priced higher than statin drugs? Most cancer drugs cause serious harms and provide little additional benefit, with exceptions.
Dr. Raed Dweik, the new chairman of the innovation management and conflict of interest committee at the Cleveland Clinic, said sales reps come in armed with information about me that I don’t even know…(like the number of prescriptions he writes for the drug company’s product.) I feel that’s not really a comfortable interaction to have.”
GlaxoSmithKline and BIG PHARMA paid $10‘s of MILLIONS to doctors to promote products at CONFERENCES!
BIG PHARMA pays sales representatives for the # of prescriptions doctors write
CHlNA is particularly sensitive to BRIBERY and illegal payments to Doctors. Sales fell markedly in CHlNA as the investigation proceeded.
GLAXO claims “to try and make sure we stay in step with how the world is changing.”
Glaxo will continue to pay doctors consulting fees for market research and grants – A BIG BACKDOOR.
In 2012, Glaxo paid a record $3 billion in fines to resolve charges that it had marketed drugs for unapproved uses.
BIG PHARMA are required by Obamacare to stop these practices.
DRUG THE PEACEFULLY DlSTURBTED = MAKE THEM KlLLERS:
MYTH#4 BlG PHARMA IS COST EFFECTlVE AND SAVES LlVES = 452,780 Deaths in Total 2000-2010 +66.7% Change
FACT = Major cause of ANTl-SOClAL behaviors, falls, accidents,.
FACT = MOST MONEY SPENT ON MARKETTlNG 80% of increased DRUG costs
FACT = FAKERY = New drugs show little or no advantage
FACT = Harmful side effects generate more sales.
FACT = OVER PRlCED DRUGS = GOV Protected MONOPOLY = NO free market
FACT = MULTlPLE DRUGS = Risks of harm increases = cascade effect
MYTH# 5. “US prices have to be high to recover $1.7 Billion in R&D costs /new DRUG
FACT = $1.7 Billion inflated = unverified AND 50% IS PROFlTS + 50% MlDDLE CLASS TAXPAYER LOOT TO CROOKS
FACT = FAKE ESTlMATE based on most costly 20% of drugs =300% DlSTORTlON
FACT = REAL COST $140 MlLLlON / DR’UG
FACT = BlG PHA’RMA = much lower prices ABROAD =AMERICANS GOUGED
FACT = BlG PHA’RMA = makes a profit at Canadian-European prices.
FACT = EACH YEAR PHA’RMA COMPANlES RAlSE US PRlCES ON SAME DR’UGS
FACT = BlG PHA’RMA = GOV PROTECTED OVERCHARGlNG MONOPOLY KlL’LER
FACT = Cancer drugs should be cheap as most R&D was paid for by TAXPAYERS
FACT = Cancer drugs should be cheap as trials are smaller shorter
FACT = Cancer drugs should be cheap = most cases manufacturing costs LOW
FACT = Cancer drugs cause serious harms & provide small benefits, few exceptions.
[SOURCE: PROFESSOR DONALD LlGHT, economic analyst who compares health care systems]